Title : Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

Pub. Date : 2018 Mar 20

PMID : 29562167






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 By virtue of a change in cellular redox homeostasis, IDH1-mutated cells synthesize excess glutamine-derived proline through enhanced activity of pyrroline 5-carboxylate reductase 1 (PYCR1), coupled to NADH oxidation. NAD isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens