Pub. Date : 2018 Feb 20
PMID : 29545933
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine acts through cholinergic nicotinic receptors, preferentially alpha7 (CHRNA7) that also binds the endogenous ligand SLURP1 (Secreted Ly-6/uPAR-Related Protein 1). | Nicotine | cholinergic receptor nicotinic alpha 7 subunit | Homo sapiens |
| 2 | Nicotine acts through cholinergic nicotinic receptors, preferentially alpha7 (CHRNA7) that also binds the endogenous ligand SLURP1 (Secreted Ly-6/uPAR-Related Protein 1). | Nicotine | cholinergic receptor nicotinic alpha 7 subunit | Homo sapiens |
| 3 | In CHRNA7high COLO357 and PANC-1 cultures, opposing activities of SLURP1 (anti-malignant/CHRNA7-dependent) and nicotine (pro-malignant/CHRNA7-infidel) were exerted without reciprocally interfering with receptor binding or downstream signaling. | Nicotine | cholinergic receptor nicotinic alpha 7 subunit | Homo sapiens |