Title : shRNA targeting of ferritin heavy chain activates H19/miR-675 axis in K562 cells.

Pub. Date : 2018 May 30

PMID : 29544765






1 Functional Relationships(s)
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1 PURPOSE: The heavy subunit of the iron storage protein ferritin (FHC) is essential for the intracellular iron metabolism and, at the same time, it represents a central hub of iron-independent pathways, such as cell proliferation, angiogenesis, p53 regulation, chemokine signalling, stem cell expansion, miRNAs expression. Iron tumor protein p53 Homo sapiens