Pub. Date : 2018 Feb 13
PMID : 29535810
12 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 2 | In this study, we addressed how silibinin enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in various cancer cells. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 3 | Combined treatment with silibinin and TRAIL (silibinin/TRAIL) induced apoptosis accompanied by the activation of caspase-3, caspase-8, caspase-9, and Bax, and cytosolic accumulation of cytochrome c. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 4 | Combined treatment with silibinin and TRAIL (silibinin/TRAIL) induced apoptosis accompanied by the activation of caspase-3, caspase-8, caspase-9, and Bax, and cytosolic accumulation of cytochrome c. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 5 | Silibinin also triggered TRAIL-induced apoptosis in A549 cells through upregulation of death receptor 5 (DR5). | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 6 | Pretreatment with DR5/Fc chimeric protein and DR5-targeted small interfering RNA (siRNA) significantly blocked silibinin/TRAIL-mediated apoptosis in A549 cells. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 7 | Furthermore, silibinin increased the production of reactive oxygen species (ROS), which led to the induction of TRAIL-mediated apoptosis through DR5 upregulation. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 8 | CHOP-targeted siRNA eliminated the induction of DR5 and resulted in a significant decrease in silibinin/TRAIL-mediated apoptosis. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 9 | We also found that silibinin/TRAIL-induced apoptosis was accompanied with intracellular influx of Ca2+, which was stimulated by ER stress and the Ca2+ chelator, ethylene glycol tetraacetic acid (EGTA). | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 10 | Ca2+/calmodulin-dependent protein kinase (CaMKII) inhibitor, K252a, blocked silibinin/TRAIL-induced DR5 expression along with TRAIL-mediated apoptosis. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 11 | Ca2+/calmodulin-dependent protein kinase (CaMKII) inhibitor, K252a, blocked silibinin/TRAIL-induced DR5 expression along with TRAIL-mediated apoptosis. | Silybin | TNF superfamily member 10 | Homo sapiens | ||
| 12 | Our results showed that silibinin enhanced TRAIL-induced apoptosis by upregulating DR5 expression through the ROS-ER stress-CaMKII-Sp1 axis. | Silybin | TNF superfamily member 10 | Homo sapiens | ||