Pub. Date : 2018 Mar 12
PMID : 29534535
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DXM significantly restored tumor necrosis factor-alpha (TNF-alpha)-mediated reduction of collagen II and decreased TNF-alpha-induced MMP-13 production. | Dextromethorphan | tumor necrosis factor | Homo sapiens |
| 2 | DXM significantly restored tumor necrosis factor-alpha (TNF-alpha)-mediated reduction of collagen II and decreased TNF-alpha-induced MMP-13 production. | Dextromethorphan | tumor necrosis factor | Homo sapiens |
| 3 | DXM significantly restored tumor necrosis factor-alpha (TNF-alpha)-mediated reduction of collagen II and decreased TNF-alpha-induced MMP-13 production. | Dextromethorphan | tumor necrosis factor | Homo sapiens |
| 4 | To inhibit the synthesis of MMP-13, DXM blocked TNF-alpha downstream signaling, including I kappa B kinase (IKK)alpha/beta-IkappaBalpha-nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK)-activator protein-1 (AP-1) activation. | Dextromethorphan | tumor necrosis factor | Homo sapiens |