Title : Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y cells.

Pub. Date : 2018 May

PMID : 29526746






3 Functional Relationships(s)
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1 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens
2 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens
3 Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells. sodium arsenite phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens