Pub. Date : 2018 Jun
PMID : 29525530
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells. | sulforaphane | microRNA 9-3 | Homo sapiens |
| 2 | Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells. | sulforaphane | microRNA 9-3 | Homo sapiens |
| 3 | In this study, we aimed to investigate the effect of SFN on restoring the miR-9-3 level in lung cancer A549 cells through epigenetic regulation. | sulforaphane | microRNA 9-3 | Homo sapiens |
| 4 | We found that CpG methylation was reduced in the miR-9-3 promoter and that miR-9-3 expression was increased after 5 days of treatment with SFN. | sulforaphane | microRNA 9-3 | Homo sapiens |
| 5 | We found that CpG methylation was reduced in the miR-9-3 promoter and that miR-9-3 expression was increased after 5 days of treatment with SFN. | sulforaphane | microRNA 9-3 | Homo sapiens |
| 6 | Taken together, these findings indicate that SFN may exert its chemopreventive effects partly through epigenetic demethylation and restoration of miR-9-3. | sulforaphane | microRNA 9-3 | Homo sapiens |