Title : COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment.

Pub. Date : 2018 Jul 1

PMID : 29514844






1 Functional Relationships(s)
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Protein Name
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1 The activation of HIF2alpha then led to the enhanced activation of VEGF, cyclin D1, and TGFalpha/EGFR pathway to mediate HCC development and reduce the sensitivity of sorafenib. Sorafenib vascular endothelial growth factor A Homo sapiens