Title : Synthesis and antinociceptive evaluation of bioisosteres and hybrids of naproxen, ibuprofen and paracetamol.

Pub. Date : 2018 May

PMID : 29514128






1 Functional Relationships(s)
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1 Our data demonstrate that compounds GUF-1, GUF-2, and GUF-5 possesses antinociceptive and antiinflammatory activities resembling and improving those known for the traditional NSAIDs, paracetamol, naproxen and ibuprofen. Naproxen GTP binding elongation factor GUF1 Rattus norvegicus