Pub. Date : 2018 May
PMID : 29498146
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 2 | We found that periostin was widely expressed in fibrotic lesions of mice with bleomycin-induced lung fibrosis, and that up-regulation of periostin expression coincided with activation of myofibroblasts positive for alpha-smooth muscle actin. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 3 | Inhibition of periostin expression by giving an intratracheal antisense oligonucleotide targeting periostin mRNA was found to suppress bleomycin-induced lung fibrosis and thereby to attenuate metastatic colonization of the lung by melanoma cells. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 4 | Inhibition of periostin expression by giving an intratracheal antisense oligonucleotide targeting periostin mRNA was found to suppress bleomycin-induced lung fibrosis and thereby to attenuate metastatic colonization of the lung by melanoma cells. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 5 | Our results indicate that periostin is a key player in the development of bleomycin-induced fibrosis and consequent enhancement of tumor cell colonization in the lung. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |