Title : Effects of bioactive constituents in the Traditional Chinese Medicinal formula Si-Wu-Tang on Nrf2 signaling and neoplastic cellular transformation.

Pub. Date : 2018 Feb 1

PMID : 29496161






1 Functional Relationships(s)
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1 RESULTS: Three of the nine compounds predicted as Nrf2 activators by molecular docking, gallic acid (GA), Z-liguistilide (LIG), and senkyunolide A (SA), were confirmed with highest potency of increasing the Nrf2/ARE promoter activity and upregulating the expression of Hmox1, Nqo1 and Slc7a11. Gallic Acid NAD(P)H quinone dehydrogenase 1 Homo sapiens