Title : Pharmacological inhibition of the Notch pathway enhances the efficacy of androgen deprivation therapy for prostate cancer.

Pub. Date : 2018 Aug 1

PMID : 29488214






1 Functional Relationships(s)
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1 As a result, pharmacological inhibition of the Notch pathway using gamma-secretase inhibitor (GSI), DAPT, downregulated both phospho-p38 and Bcl-2 expression and significantly enhanced the efficacy of ADT in androgen sensitive PCa cells with impaired proliferation and 3D colony formation, increased apoptosis and remarkable inhibition of tumor growth in murine subcutaneous xenograft model. dapt notch receptor 3 Homo sapiens