Title : 17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.

Pub. Date : 2018

PMID : 29481571






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabilizes client proteins and directs them towards proteosomal degradation. tanespimycin heat shock protein, 2 Mus musculus
2 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabilizes client proteins and directs them towards proteosomal degradation. tanespimycin heat shock protein, 2 Mus musculus