Title : Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates.

Pub. Date : 2018 Mar 14

PMID : 29473076

1 Functional Relationships(s)
Compound Name
Protein Name
1 These linkers vary by both cleavable trigger motif and hydrophilicity, containing one of two cathepsin B sensitive dipeptides (Val-Cit and Val-Ala), and engendered with either hydrophilic or hydrophobic character via application of a PEG12 spacer. Dipeptides cathepsin B Homo sapiens