Title : Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor.

Pub. Date : 2018 Aug

PMID : 29471110






5 Functional Relationships(s)
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1 Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons aryl hydrocarbon receptor Rattus norvegicus
2 The binding of B(a)P to the aryl hydrocarbon (Ah) receptor was similarly modulated by other PAHs. Polycyclic Aromatic Hydrocarbons aryl hydrocarbon receptor Rattus norvegicus
3 No correlation was evident between binding avidity of the PAH to the Ah receptor and either its potential for interaction or nature of interaction, e.g. synergism or antagonism. Polycyclic Aromatic Hydrocarbons aryl hydrocarbon receptor Rattus norvegicus
4 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons aryl hydrocarbon receptor Rattus norvegicus
5 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons aryl hydrocarbon receptor Rattus norvegicus