Pub. Date : 2018 Apr 1
PMID : 29471073
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that etoposide and ellipticine induced CYP1A1 in TP53(+/+) cells but not in TP53(-/-) cells, demonstrating that the mechanism of CYP1A1 induction is p53-dependent; cisplatin had no such effect. | Etoposide | tumor protein p53 | Homo sapiens |
2 | We found that etoposide and ellipticine induced CYP1A1 in TP53(+/+) cells but not in TP53(-/-) cells, demonstrating that the mechanism of CYP1A1 induction is p53-dependent; cisplatin had no such effect. | Etoposide | tumor protein p53 | Homo sapiens |
3 | Co-incubation experiments with the drugs and 2.5 muM BaP showed that: (i) etoposide increased CYP1A1 expression in TP53(+/+) cells, and to a lesser extent in TP53(-/-) cells, compared to cells treated with BaP alone; (ii) ellipticine decreased CYP1A1 expression in TP53(+/+) cells in BaP co-incubations; and (iii) cisplatin did not affect BaP-mediated CYP1A1 expression. | Etoposide | tumor protein p53 | Homo sapiens |
4 | Our results indicate that the underlying mechanisms whereby etoposide and ellipticine regulate CYP1A1 expression must be different and may not be linked to p53 activation alone. | Etoposide | tumor protein p53 | Homo sapiens |