Title : Macrophages and CD8+ T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors.

Pub. Date : 2018 Apr

PMID : 29467128






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activated TAMs had greater TNFalpha production and NFkappaB signaling and directly inhibited tumor cells in vitro Anti-CD40 required concomitant therapy with imatinib for efficacy and depended on TAMs, and to a lesser extent CD8+ T cells, but not on CD4+ T cells or B cells. tams CD8a molecule Homo sapiens