Pub. Date : 2018 Jan
PMID : 29463407
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of genetic polymorphism of human CYP2B6 on the metabolic activation of chlorpyrifos. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Chlorpyrifos oxon (CPO) is a toxic metabolite of CPS that is produced by CYP2B6. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In this study, we examined the variability of CPS metabolism resulting from single-nucleotide polymorphisms in CYP2B6. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | The conversion of CPS to CPO by the CYP2B6 variants was analyzed with high-performance liquid chromatography. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | These results indicate that the amino acid substitutions in the CYP2B6 variants suppressed the metabolic activation of CPS. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |