Title : Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor.

Pub. Date : 2018 Feb 8

PMID : 29456803






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A cocrystal structure of 18 with a NS3/4A protease complex suggests the presence of a H-bond between the polarized C-H of the CHF2 moiety and the backbone carbonyl of Leu135 of the enzyme. Carbon hes related family bHLH transcription factor with YRPW motif 1 Homo sapiens