Title : Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.

Pub. Date : 2018 May 1

PMID : 29452354






4 Functional Relationships(s)
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1 In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer. Iron ferroxidase FET3 Saccharomyces cerevisiae S288C
2 When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation. Iron ferroxidase FET3 Saccharomyces cerevisiae S288C
3 When the concentration of external iron is low (<1 microM), Fet3/Ftr1 is maintained on the plasma membrane by retrograde endocytic-recycling; whereas, when the concentration of external iron is high (>10 microM), Fet3/Ftr1 is endocytosed and shunted to the vacuole for degradation. Iron ferroxidase FET3 Saccharomyces cerevisiae S288C
4 We discovered that alpha-syn expression phenocopies the high iron condition: under the low iron condition (<1 microM), alpha-syn inhibits Snx3-retromer-mediated recycling of Fet3/Ftr1 and instead shunts Fet3/Ftr1 into the multivesicular body pathway to the vacuole. Iron ferroxidase FET3 Saccharomyces cerevisiae S288C