Pub. Date : 2018 Nov
PMID : 29446047
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway. | epigallocatechin gallate | forkhead box O1 | Rattus norvegicus |
| 2 | EGCG activated SIRT1 and increased FOXO1 expression, whose expression trend was consistent with the fenofibrate group. | epigallocatechin gallate | forkhead box O1 | Rattus norvegicus |
| 3 | Simultaneously, EGCG increased FOXO1 expression, and decrease SREBP-2 expression; however, no significant changes in these expression were found in SREBP-2-/- rats. | epigallocatechin gallate | forkhead box O1 | Rattus norvegicus |
| 4 | EGCG can activate SIRT1, activate FOXO1 protein, regulate SREBP-2 protein, and inhibit hepatic cholesterol synthesis. | epigallocatechin gallate | forkhead box O1 | Rattus norvegicus |