Title : Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies.

Pub. Date : 2018 Feb 11

PMID : 29439493






2 Functional Relationships(s)
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Protein Name
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1 Isocitrate dehydrogenases 1 and 2 (IDH1,2), the key Krebs cycle enzymes that generate NADPH reducing equivalents, undergo heterozygous mutations in >70% of low- to mid-grade gliomas and ~20% of acute myeloid leukemias (AMLs) and gain an unusual new activity of reducing the alpha-ketoglutarate (alpha-KG) to D-2 hydroxyglutarate (D-2HG) in a NADPH-consuming reaction. Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Isocitrate dehydrogenases 1 and 2 (IDH1,2), the key Krebs cycle enzymes that generate NADPH reducing equivalents, undergo heterozygous mutations in >70% of low- to mid-grade gliomas and ~20% of acute myeloid leukemias (AMLs) and gain an unusual new activity of reducing the alpha-ketoglutarate (alpha-KG) to D-2 hydroxyglutarate (D-2HG) in a NADPH-consuming reaction. Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens