Title : Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.

Pub. Date : 2018 Feb 7

PMID : 29437146






1 Functional Relationships(s)
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1 We demonstrate that ITF2357 (givinostat), a clinical-stage inhibitor of histone deacetylase (HDAC) catalytic activity, is efficacious in two distinct murine models of diastolic dysfunction with preserved EF. givinostat histone deacetylase 9 Homo sapiens