Title : Metformin inhibits the migration and invasion of esophageal squamous cell carcinoma cells by downregulating the protein kinase B signaling pathway.

Pub. Date : 2018 Mar

PMID : 29435022






2 Functional Relationships(s)
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1 A Transwell assay and western blot analysis revealed that metformin inhibited the migration and invasion of EC109 cells, nuclear factor-kappaB activation, matrix metallopeptidase 9 and N-cadherin expression in a phosphorylated-AKT dependent manner. Metformin AKT serine/threonine kinase 1 Homo sapiens
2 These results suggested that metformin inhibits the migration and invasion of human esophageal carcinoma cells by suppressing AKT phosphorylation and regulating the expression of migration- and invasion-associated genes. Metformin AKT serine/threonine kinase 1 Homo sapiens