Title : Dihydroartemisinin treatment of multiple myeloma cells causes activation of c-Jun leading to cell apoptosis.

Pub. Date : 2018 Feb

PMID : 29434974






3 Functional Relationships(s)
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1 RT-PCR analysis of DHA-treated or -untreated U266 cells after 48 h demonstrated a significant (P<0.01) increase in caspase-3 expression. artenimol caspase 3 Homo sapiens
2 The addition of SP600125 to the cells incubated with DHA resulted in a significant decrease in the caspase-3 and c-Jun expression levels compared with those cells incubated with DHA alone. artenimol caspase 3 Homo sapiens
3 These findings confirm that treatment with DHA increased caspase-3 and c-Jun expression in the U266 cells through activation of the JNK signaling pathway. artenimol caspase 3 Homo sapiens