Title : CO2/bicarbonate modulates cone photoreceptor ROS-GC1 and restores its CORD6-linked catalytic activity.

Pub. Date : 2018 Nov

PMID : 29427171






1 Functional Relationships(s)
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1 Mechanistically, CO2 is sensed by carbonic anhydrase (CAII), generates bicarbonate that, in turn, directly targets the core catalytic domain of ROS-GC1, and activates it to increased synthesis of cyclic GMP. Bicarbonates carbonic anhydrase 2 Homo sapiens