Pub. Date : 2018 Jan
PMID : 29424887
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MiR-205 enhances cisplatin sensitivity of glioma cells by targeting E2F1. | Cisplatin | microRNA 205 | Homo sapiens |
| 2 | The current research aimed to decipher the role of miR-205 in the development of cisplatin resistance in glioma cells. | Cisplatin | microRNA 205 | Homo sapiens |
| 3 | MATERIALS AND METHODS: miR-205 expressions in both cisplatin sensitive and resistant cell lines were compared by the Real-time PCR method. | Cisplatin | microRNA 205 | Homo sapiens |
| 4 | RESULTS: miR-205 expression was decreased in cisplatin resistant glioma cell lines, and cisplatin treatment led to a decrease of miR-205 in glioma cells. | Cisplatin | microRNA 205 | Homo sapiens |
| 5 | RESULTS: miR-205 expression was decreased in cisplatin resistant glioma cell lines, and cisplatin treatment led to a decrease of miR-205 in glioma cells. | Cisplatin | microRNA 205 | Homo sapiens |
| 6 | Overexpression of miR-205 in U87/DDP restored its cisplatin sensitivity by enhancing apoptosis and G1/S cell cycle arrest; notably, all these effects were then partially abrogated by E2F1 overexpression. | Cisplatin | microRNA 205 | Homo sapiens |
| 7 | CONCLUSIONS: These findings suggest that down-regulation of miR-205 confers the cisplatin resistance in glioma cells via upregulation of E2F1. | Cisplatin | microRNA 205 | Homo sapiens |