Title : Design and synthesis of new potent N,N-bis(arylalkyl)piperazine derivatives as multidrug resistance (MDR) reversing agents.

Pub. Date : 2018 Mar 10

PMID : 29421572






1 Functional Relationships(s)
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1 The most potent compounds, 8, 9, 10 and 13, were further studied by evaluating their doxorubicin cytotoxicity enhancement (reversal fold, RF) and the inhibition of P-gp-mediated rhodamine-123 (Rhd 123) efflux on the K562/DOX cell line. Rhodamine 123 phosphoglycolate phosphatase Homo sapiens