Pub. Date : 2018 Feb 7
PMID : 29415984
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that stable knockdown of UHRF1 renders retinoblastoma cells sensitized to conventional chemotherapeutic drugs such as etoposide and camptothecin, resulting in enhanced DNA damage and apoptotic cell death. | Etoposide | ubiquitin like with PHD and ring finger domains 1 | Homo sapiens |
| 2 | Conversely, overexpression of UHRF1 increased the XRCC4 expression and stable knockdown of XRCC4 sensitized retinoblastoma cells to etoposide treatment, suggesting that XRCC4 is a key mediator for the drug sensitivity upon UHRF1 depletion in retinoblastoma cells. | Etoposide | ubiquitin like with PHD and ring finger domains 1 | Homo sapiens |