Title : Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.

Pub. Date : 2018 Mar

PMID : 29408579






2 Functional Relationships(s)
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1 In MDA-MB-468 cells that were coincubated with the CYP1 inhibitor acacetin, an approximately 300-fold increase was noted in the IC50 (30 +- 2.4 muM) of nobiletin. nobiletin latexin Homo sapiens
2 Furthermore, a significant increase was noted in the population of the cells at the G1 phase, following treatment with nobiletin (10 muM) for 24 h compared with the control cells treated with DMSO (0.1%) alone (55.9 +- 0.14 vs. 45.6 +- 1.96), whereas the cell cycle of MCF10A cells was not significantly altered under the same treatment conditions. nobiletin latexin Homo sapiens