Title : beta-Endorphin-induced stimulation of central sympathetic outflow: inhibitory modulation by central noradrenergic neurons.

Pub. Date : 1986 Jun

PMID : 2940358






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1 administration of synthetic human beta-endorphin to increase plasma catecholamine concentrations, presumably by acting at opioid receptors in the brain to stimulate the central sympathetic outflow to adrenal medulla and peripheral sympathetic nerve terminals. Catecholamines proopiomelanocortin Homo sapiens
2 This beta-endorphin-induced increase in plasma catecholamine concentration is dose-dependent, inhibited by naloxone and blocked by bilateral adrenal gland denervation or ganglionic blockade with chlorisondamine. Catecholamines proopiomelanocortin Homo sapiens
3 In this study we examined the possibility of central noradrenergic regulation of beta-endorphin-induced catecholamine secretion. Catecholamines proopiomelanocortin Homo sapiens
4 norepinephrine on beta-endorphin-induced catecholamine secretion. Catecholamines proopiomelanocortin Homo sapiens
5 norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment. Catecholamines proopiomelanocortin Homo sapiens