Title : Inhibition of MUS81 improves the chemical sensitivity of olaparib by regulating MCM2 in epithelial ovarian cancer.

Pub. Date : 2018 Apr

PMID : 29393493






1 Functional Relationships(s)
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1 Methyl methanesulfonate and ultraviolet sensitive gene clone 81 (MUS81), a key endonuclease in DNA repair, is generally considered a tumor suppressor; however, recent studies have revealed its tumor-promoting effect in epithelial ovarian cancer (EOC) and have shown that its overexpression is associated with cisplatin sensitization. Cisplatin MUS81 structure-specific endonuclease subunit Homo sapiens