Title : Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4).

Pub. Date : 2018 Jan 31

PMID : 29385093






3 Functional Relationships(s)
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1 We demonstrate that sFRP4 has a prominent role in basal glucose uptake in CSCs derived from breast and prostate tumour cell lines. Glucose secreted frizzled related protein 4 Homo sapiens
2 We show that sFRP4 treatment on CSCs isolated with variable glucose content induces metabolic reprogramming by relocating metabolic flux to glycolysis or OXPHOS. Glucose secreted frizzled related protein 4 Homo sapiens
3 Altogether, sFRP4 treatment compromises cell proliferation and critically affects cell survival mechanisms such as viability, glucose transporters, pyruvate conversion, mammalian target of rapamycin, and induces CSC apoptosis under conditions of variable glucose content. Glucose secreted frizzled related protein 4 Homo sapiens