Pub. Date : 2018 Jan 31
PMID : 29385093
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We demonstrate that sFRP4 has a prominent role in basal glucose uptake in CSCs derived from breast and prostate tumour cell lines. | Glucose | secreted frizzled related protein 4 | Homo sapiens |
2 | We show that sFRP4 treatment on CSCs isolated with variable glucose content induces metabolic reprogramming by relocating metabolic flux to glycolysis or OXPHOS. | Glucose | secreted frizzled related protein 4 | Homo sapiens |
3 | Altogether, sFRP4 treatment compromises cell proliferation and critically affects cell survival mechanisms such as viability, glucose transporters, pyruvate conversion, mammalian target of rapamycin, and induces CSC apoptosis under conditions of variable glucose content. | Glucose | secreted frizzled related protein 4 | Homo sapiens |