Pub. Date : 2018 Feb 13
PMID : 29382760
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The reduced expression of the Cl--extruding cotransporter KCC2 is accompanied by an increase in the Cl--importing cotransporter NKCC1, which together result in excitatory GABA in the hippocampi of HD mice. | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |
| 2 | NKCC1 inhibition by the FDA-approved NKCC1 inhibitor bumetanide abolished the excitatory action of GABA and rescued the performance of R6/2 mice on hippocampal-associated behavioral tests. | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |
| 3 | NKCC1 inhibition by the FDA-approved NKCC1 inhibitor bumetanide abolished the excitatory action of GABA and rescued the performance of R6/2 mice on hippocampal-associated behavioral tests. | gamma-Aminobutyric Acid | solute carrier family 12, member 2 | Mus musculus |