Title : IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers.

Pub. Date : 2018 Apr 2

PMID : 29381485






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol X-box binding protein 1 Homo sapiens
2 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol X-box binding protein 1 Homo sapiens