Title : Thyroid hormone and the brain: Mechanisms of action in development and role in protection and promotion of recovery after brain injury.

Pub. Date : 2018 Jun

PMID : 29378220






2 Functional Relationships(s)
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1 Additional factors that impact TH action in the brain include metabolism, activation of thyroxine (T4) to triiodothyronine (T3) by the enzyme 5"-deiodinase Type 2 (Dio2), inactivation by the enzyme 5-deiodinase Type 3 (Dio3) to reverse T3 (rT3), which occurs in glial cells, and uptake by the Mct8 transporter in neurons. Triiodothyronine iodothyronine deiodinase 2 Homo sapiens
2 Additional factors that impact TH action in the brain include metabolism, activation of thyroxine (T4) to triiodothyronine (T3) by the enzyme 5"-deiodinase Type 2 (Dio2), inactivation by the enzyme 5-deiodinase Type 3 (Dio3) to reverse T3 (rT3), which occurs in glial cells, and uptake by the Mct8 transporter in neurons. Triiodothyronine iodothyronine deiodinase 2 Homo sapiens