Pub. Date : 2017
PMID : 29375379
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages. | scutellarin | interleukin 1 beta | Mus musculus |
| 2 | The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages. | scutellarin | interleukin 1 beta | Mus musculus |
| 3 | As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli. | scutellarin | interleukin 1 beta | Mus musculus |
| 4 | In line with this, scutellarin treatment significantly reduced serum IL-1beta levels and attenuated the infiltration of inflammatory cells in the liver of E. coli-infected mice. | scutellarin | interleukin 1 beta | Mus musculus |