Pub. Date : 2018 Apr 10
PMID : 29373839
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel. | Paclitaxel | NUS1 dehydrodolichyl diphosphate synthase subunit | Homo sapiens |
| 2 | Here, we demonstrate NgBR as a potential therapeutic target for ERalpha positive breast cancer patients to attenuate paclitaxel resistance. | Paclitaxel | NUS1 dehydrodolichyl diphosphate synthase subunit | Homo sapiens |
| 3 | NgBR knockdown enhanced paclitaxel-induced cell apoptosis by modulating expression of p53 and survivin in ERalpha positive breast cancer cells via NgBR-mediated PI3K/Akt and MAPK/ERK signaling pathways. | Paclitaxel | NUS1 dehydrodolichyl diphosphate synthase subunit | Homo sapiens |
| 4 | NgBR knockdown enhanced paclitaxel-induced cell apoptosis by modulating expression of p53 and survivin in ERalpha positive breast cancer cells via NgBR-mediated PI3K/Akt and MAPK/ERK signaling pathways. | Paclitaxel | NUS1 dehydrodolichyl diphosphate synthase subunit | Homo sapiens |
| 5 | In summary, our data suggest that NgBR expression is essential to promoting ERalpha positive breast cancer cell resistance to paclitaxel. | Paclitaxel | NUS1 dehydrodolichyl diphosphate synthase subunit | Homo sapiens |