Pub. Date : 2018 Apr 15
PMID : 29371085
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | (E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol attenuates PMA-induced inflammatory responses in human monocytic cells through PKCdelta/JNK/AP-1 pathways. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | MMPP inhibited PMA-induced membrane translocation of PKCdelta, phosphorylation of JNK, and nuclear translocation of AP-1, resulting in downregulation of cyclooxygenase-2 and chemokine ligand 5 production. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | These findings indicate that MMPP inhibits inflammatory responses in THP-1 cells by mitigating PMA-induced activation of PKCdelta and JNK and nuclear translocation of AP-1. | Tetradecanoylphorbol Acetate | JunB proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |