Title : Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3.

Pub. Date : 2018 Mar

PMID : 29360536






1 Functional Relationships(s)
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1 Two steroids with a 4-fluorinated benzoic acid ester at C-21 were the most active against lung cancer cell line with IC50 of 13.1 +- 1.2 and 12.8 +- 0.5 muM and showed a low percentage of cytotoxicity for noncancerous cells (27.63 +- 2.3 and 18.39 +- 1.2% in the screening at 50 muM). Steroids TBL1X/Y related 1 Homo sapiens