Title : Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine-Based Hydroxamates for the Treatment of Hepatocellular Carcinoma.

Pub. Date : 2018 Feb 22

PMID : 29360358






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway was involved in the development of HCC and acquired resistance to sorafenib. Sorafenib AKT serine/threonine kinase 1 Homo sapiens
2 Activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway was involved in the development of HCC and acquired resistance to sorafenib. Sorafenib AKT serine/threonine kinase 1 Homo sapiens