Title : Low-level overexpression of p53 promotes warfarin-induced calcification of porcine aortic valve interstitial cells by activating Slug gene transcription.

Pub. Date : 2018 Mar 9

PMID : 29358327






3 Functional Relationships(s)
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1 Low-level overexpression of p53 in pAVICs via an adenovirus vector did not affect pAVIC apoptosis but promoted warfarin-induced calcium deposition and expression of osteogenic markers. Calcium tumor protein p53 Homo sapiens
2 shRNA-mediated p53 knockdown attenuated the pAVIC calcium deposition and osteogenic marker expression. Calcium tumor protein p53 Homo sapiens
3 Of note, overexpression of Slug increased osteogenic marker Runx2 expression, but not pAVIC calcium deposition, and Slug knockdown attenuated pAVIC calcification and p53-mediated pAVIC calcium deposition and expression of osteogenic markers. Calcium tumor protein p53 Homo sapiens