Title : Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.

Pub. Date : 2017 Dec 22

PMID : 29348854






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ASAH1 is identified as a de novo glioblastoma drug target, and ASAH1 inhibitors, such as carmofur, are shown to be highly effective and to specifically target glioblastoma GSCs. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens
2 Carmofur is an ASAH1 inhibitor that crosses the blood-brain barrier, a major bottleneck in glioblastoma treatment. carmofur N-acylsphingosine amidohydrolase 1 Homo sapiens