Title : Membrane-permeable Rab27A is a regulator of the acrosome reaction: Role of geranylgeranylation and guanine nucleotides.

Pub. Date : 2018 Apr

PMID : 29337043






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 When GDP-beta-S substituted for GTP-gamma-S, isoprenylated TAT-Rab27A inhibited the acrosome reaction triggered by progesterone and an Epac-selective cAMP analogue, whereas the non-isoprenylated protein did not. guanosine 5'-O-(2-thiodiphosphate) RAB27A, member RAS oncogene family Homo sapiens
2 In contrast, TAT-Rab27A lacking isoprenylation or loaded with GDP-beta-S prevented the activation of Rab3 and Rap1 elicited by progesterone. guanosine 5'-O-(2-thiodiphosphate) RAB27A, member RAS oncogene family Homo sapiens