Title : Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody.

Pub. Date : 2018 Apr

PMID : 29333938






2 Functional Relationships(s)
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Protein Name
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1 Insertion of two glycines in both the heavy and light chain elbow regions provided sufficient flexibility for the variable domains to extend further apart than the wild-type Fab, and allow the CDR3s to make additional interactions not seen in the wild-type Fab structure. Glycine FA complementation group B Homo sapiens
2 Insertion of two glycines in both the heavy and light chain elbow regions provided sufficient flexibility for the variable domains to extend further apart than the wild-type Fab, and allow the CDR3s to make additional interactions not seen in the wild-type Fab structure. Glycine FA complementation group B Homo sapiens