Title : Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity.

Pub. Date : 2018 Mar 20

PMID : 29324279






3 Functional Relationships(s)
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1 Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity. Mercaptopurine UDP-glucose 6-dehydrogenase Homo sapiens
2 Inhibition of UDP-glucose dehydrogenase by 6-thiopurine and its oxidative metabolites: Possible mechanism for its interaction within the bilirubin excretion pathway and 6TP associated liver toxicity. Mercaptopurine UDP-glucose 6-dehydrogenase Homo sapiens
3 Our results show that the C2 and C8 positions of 6TP are pivotal in said inhibition towards UDPGDH and have no effect upon UGT1A1, and that blocking C8 could lead to new analogs with reduced, if not eliminated jaundice and liver toxicities. Mercaptopurine UDP-glucose 6-dehydrogenase Homo sapiens