Pub. Date : 2018
PMID : 29317830
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway. | Quercetin | tumor protein p53 | Homo sapiens |
| 2 | However, the role of tumor suppressor p53 on quercetin"s radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. | Quercetin | tumor protein p53 | Homo sapiens |
| 3 | Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expression of p53 protein; phosphorylation on serine 15 and 20 increased in combination with X-irradiation. | Quercetin | tumor protein p53 | Homo sapiens |
| 4 | Knocking down of p53 could reverse all the above effects under quercetin in combination with radiation. | Quercetin | tumor protein p53 | Homo sapiens |
| 5 | In human ovarian cancer xenograft model, combined treatment of quercetin and radiation significantly restrained the growth of tumors, accompanied with the activation of p53, CCAAT/enhancer-binding protein homologous protein, and gamma-H2AX. | Quercetin | tumor protein p53 | Homo sapiens |
| 6 | Overall, these results indicated that quercetin acted as a promising radiosensitizer through p53-dependent ER stress signals. | Quercetin | tumor protein p53 | Homo sapiens |