Title : De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease.

Pub. Date : 2017

PMID : 29311779






1 Functional Relationships(s)
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1 In particular, reduction in the levels of sptlc1 and cerS1 mRNA in the brain tissues from manifest HD mice resulted in a significant decrease in the content of dihydroSphingosine, dihydroSphingosine-1-phospahte and dihydroCeramide [C18:0] as assessed by mass spectrometry. safingol ceramide synthase 1 Mus musculus