Pub. Date : 2018 Apr
PMID : 29310825
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 2 | Kir4.1 in the distal convoluted tubule plays a key role in sensing plasma potassium and in modulating the thiazide-sensitive sodium-chloride cotransporter (NCC). | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 3 | High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 4 | High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 5 | High potassium intake inhibited the basolateral 40 pS potassium channel (a Kir4.1/5.1 heterotetramer) in the distal convoluted tubule, decreased basolateral potassium conductance, and depolarized the distal convoluted tubule membrane in Kcnj10flox/flox mice, herein referred to as control mice. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 6 | In contrast, low potassium intake activated Kir4.1, increased potassium currents, and hyperpolarized the distal convoluted tubule membrane. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 7 | These effects of dietary potassium intake on the basolateral potassium conductance and membrane potential in the distal convoluted tubule were completely absent in inducible kidney-specific Kir4.1 knockout mice. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 8 | Finally, hypokalemia and metabolic alkalosis in kidney-specific Kir4.1 knockout mice were exacerbated by potassium restriction and only partially corrected by a high-potassium diet. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 9 | Finally, hypokalemia and metabolic alkalosis in kidney-specific Kir4.1 knockout mice were exacerbated by potassium restriction and only partially corrected by a high-potassium diet. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 10 | Thus, Kir4.1 plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 11 | Thus, Kir4.1 plays an essential role in mediating the effect of dietary potassium intake on NCC activity and potassium homeostasis. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |