Title : Exploration of charge states of balanol analogues acting as ATP-competitive inhibitors in kinases.

Pub. Date : 2017 Dec 28

PMID : 29297286






2 Functional Relationships(s)
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Protein Name
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1 BACKGROUND: (-)-Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. Adenosine Triphosphate protein kinase C epsilon Homo sapiens
2 CONCLUSIONS: To the best our knowledge, this is the first study showing that the phenolate group is charged in balanol and its analogues binding to the ATP site of PKCepsilon. Adenosine Triphosphate protein kinase C epsilon Homo sapiens